Ramachandran Srinivasan

Impact

Sustainable applications of plant biotechnology research can increase the yield and stress tolerance of commercial crops, as well as control urban air pollutants with nature-based solutions. Sri hopes that plant research can help achieve Singapore’s goals of halving carbon emissions by 2050, and food security by 2030.

Collaborations, Achievements & Honours

  • Developed a plant-based ioniser that led to spin-off Zero2.5 Biotech, a company that specialises in generating negative air ions under pulsed electrical field treatment, efficiently reducing PM2.5 concentration and removal of aerosol particles, viruses, bacteria and fungi in closed chambers
  • Bred leafy vegetable varieties with higher biomass and nutritional content through Polyploidy, EMS mutagenesis and formulation of in-house medium
  • Identified T3 fraction, a Jatropha seed inner skin based larvicide for safe mosquito control
  • Headed first commercial scale Jatropha project in Ghana, sustainably transforming marginal lands into viable plantations at JOil (2021)
  • Spearheaded breeding programme for commercial Jatropha varieties at JOil (2008)
  • Research collaboration with Singapore National Parks Board on propagating critically endangered tree species
  • Research collaboration with Rivulis on integrating drip irrigation solution via bio-stimulant cocktail to increase yield, reduce water and fertiliser inputs, as well as methane emissions
  • Research collaboration with the Singapore Institute of Materials Research and Engineering to mitigate COVID-19 with plant-based negative air ion generators via aerosol removal
  • Research collaboration with Netatech on sustainably producing crops in Vertical Food Stage urban farming system
  • Granted research by Temasek Foundation, the Singapore National Research Foundation and Singapore Manufacturing Federation (2015 – 2024)

Research Areas

Agronomy, Ecological Biology, Genetics & Genomics

Affiliations

  • Senior Principal Investigator, TLL

Question

How do we develop better crop varieties and plant-based applications through genetics, genomics and agronomy?

Approach

Sri’s lab discovered that plant-based ionisers, which electrically charge PM2.5 particles and efficiently remove them with negative air ions, can be generated at approximately 100 x 106 ions/ cm³ under pulsed electrical field treatment. This was found to reduce PM2.5 concentration from less than 500 µg/m³ to nearly 0 µg/m³ within five minutes in a closed chamber. Concurrently, plant-based ionisers have also shown potential application in removing aerosol particles, viruses, bacteria and fungi in air.

Sri’s lab developed polyploidy varieties of Choy Sum, Kai Lan and white Bok Choy with over 10% higher biomass and antioxidants. Similar varieties are being bred with EMS mutagenesis. A nutrient medium formulation was also identified to increase lettuce biomass in Kale, red Oak Leaf and Romaine lettuce by up to 30% higher. The medium is further tested on other leafy vegetable varieties and rice.

Through toxicological studies, Sri’s lab identified T3 fraction, a Jatropha seed inner skin based larvicide for safe mosquito control. He continues to propagate and supply critically endangered tree species of Singapore through research collaborations with the National Parks Board.

Simultaneously, Sri aims to develop strategies for carbon farming, using tree species to reduce footprint and explore carbon credit potential. The approach includes an integrated drip irrigation solution with bio-stimulant cocktail to mitigate methane missions in rice fields.

Sri’s lab is also developing a bio-glue to replace toxic Urea Formaldehyde based formulations in wood panel industries. It was found that cotton seed meal and Jatropha kernel meal-based bio-resin formulations worked well with plywood of single species veneers, specifically poplar, eucalyptus and rubberwood in lab and industrial trials.

Bio

Dr. Sri is a distinguished researcher in the field of Biochemistry with a specialization in Plant Molecular Biology. He earned his Ph.D. from the University of Idaho, where he conducted groundbreaking research under the mentorship of Prof. David Oliver. In 1993, he joined Prof. Nam Hai Chua’s group at the Institute of Molecular and Cell Biology and Institute of Molecular Agrobiology in Singapore. For the past two decades, Dr. Sri has been at the forefront of Rice Functional Genomics, leading significant research initiatives at the Institute of Molecular Biology and, since August 2002, at the Temasek Life Sciences Laboratory. He concurrently served as Chief Technology Officer at JOil, a spin-off company focused on the development of commercial Jatropha varieties, from 2008 to 2021. Since 2014, Dr Sri also holds the position of Adjunct Associate Professor at the School of Biological Sciences, Nanyang Technological University, Singapore.

Dr. Sri’s rich experience in conducting and supervising large-scale overseas field trials in places including Indonesia, Burkina Faso, India, Hainan (China), and Ghana positions him as a strategic project lead for the Phase 2a project expansion to Laos, Indonesia, and India. Dr. Sri is currently leading the small-scale test-bedding in India and Singapore to reduce methane emissions in rice production. He is the overall R&D planning and execution with partners in the proposed Phase 2a regions.

Senior Principal Investigator

Ramachandran Srinivasan

The lab focuses on sustainable applications of plant biotechnology research and agronomy practices that increase the yield and stress tolerance of commercial crops.

Group Publications